Bombesin

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Bombesin

Identifiers
CAS number	31362-50-2
PubChem	16133891
Properties
Molecular formula	C₇₁H₁₁₀N₂₄O₁₈S
Molar mass	1619.85
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox references

Bombesin is a 14 amino acid peptide originally isolated from the skin of a frog. It has two known homologs in mammals called neuromedin B and gastrin releasing peptide. It stimulates gastrin release from G cells. It activates three different G-protein coupled receptors known as BBR1 2 & 3. It also activates these receptors in the brain. Together with cholecystokinin it is the second major source of negative feedback signals that stop eating behaviour.

Bombesin is also a tumor marker for lung cancer, gastric cancer and neuroblastoma.

Peptides: neuropeptides

Hypothalamic	Somatostatin - CRH - GnRH - GHRH - Orexins - TRH - POMC (ACTH, MSH, Lipotropin)

Gastrointestinal hormones	Cholecystokinin - Gastric inhibitory polypeptide - Gastrin - Motilin - Secretin - Vasoactive intestinal peptide

Other hormones	Vasopressin - Calcitonin -

Other	Angiotensin - Bombesin/Neuromedin B - Calcitonin gene-related peptide - Carnosine - Delta sleep-inducing peptide - FMRFamide - Galanin - Gastrin releasing peptide - Kinins (Bradykinin, Tachykinins ) - Neuromedin (B, N, U) - Neuropeptide Y - Neurophysins - Neurotensin - Opioid peptide - Pancreatic polypeptide - Pituitary adenylate cyclase activating peptide

This article is from Wikipedia. All text is available under the terms of the GNU Free Documentation License.

See also