VCX:

This gene belongs to the VCX/Y gene family, which has multiple members on both X and Y chromosomes, and all are expressed exclusively in male germ cells. The X-linked members are clustered on chromosome Xp22 and Y-linked members are two identical copies of the gene within a palindromic region on Yq11. The family members share a high degree of sequence identity, with the exception that a 30-bp unit is tandemly repeated in X-linked members but occurs only once in Y-linked members. The VCX gene cluster is polymorphic in terms of copy number; different individuals may have a different number of VCX genes. VCX/Y genes encode small and highly charged proteins of unknown function. The presence of a putative bipartite nuclear localization signal suggests that VCX/Y members are nuclear proteins. This gene contains 10 repeats of the 30-bp unit.^[1]

Zou SW, Zhang JC, Zhang XD, et al. (2004). "Expression and localization of VCX/Y proteins and their possible involvement in regulation of ribosome assembly during spermatogenesis.". Cell Res. 13 (3): 171-7. doi:10.1038/sj.cr.7290161. PMID 12862317.
Sy SM, Wong N, Mok TS, et al. (2003). "Genetic alterations of lung adenocarcinoma in relation to smoking and ethnicity.". Lung Cancer 41 (1): 91-9. PMID 12826317.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Fukami M, Kirsch S, Schiller S, et al. (2000). "A member of a gene family on Xp22.3, VCX-A, is deleted in patients with X-linked nonspecific mental retardation.". Am. J. Hum. Genet. 67 (3): 563-73. PMID 10903929.
Lahn BT, Page DC (2000). "A human sex-chromosomal gene family expressed in male germ cells and encoding variably charged proteins.". Hum. Mol. Genet. 9 (2): 311-9. PMID 10607842.

VCX

References

Further reading